DW Insights & Inquiries
Lipoid proteinosis was described almost a century ago. Genetic discoveries have yet to translate into precise therapeutic interventions. Acitretin remains the systemic treatment of choice.
Rapidly progressing interstitial lung disease and pneumomediastinum are potentially life-threatening complications of anti-MDA5-postiive dermatomyositis. Dyspneic patients with this disease mandate urgent assessment.
Heat shock protein inhibition is a novel approach that may prove valuable for dermatologists treating inflammatory, autoimmune, bullous, and oncologic diseases.
Maintaining the skin barrier is crucial in managing patients with atopic dermatitis. Research on newly discovered proteins in the stratum corneum, such as hornerin, may lead to novel therapeutic interventions.
The rare phenomenon of tumoral melanosis may become more common with advances in melanoma immunotherapy. Such cases may have a better prognosis than cases of TM due to regression from advanced disease.
CTCL during pregnancy presents unique challenges. Many standard therapies are contraindicated; topical steroids, phototherapy, and interferon are considered safe options. A multidisciplinary approach is necessary for optimal management.
To improve the practice of dermatology, while being stimulating, practical, thought-provoking, and enlightening by offering critical perspectives on current dermatologic literature meant to be used in the clinic today and in the future.
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