DW Insights & Inquiries
Advances in genetics and molecular biology have identified pathways confirming the usefulness of targeted therapies in those patients with systemic juvenile xanthogranulomas harboring specific mutations.
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IGM should be considered in inflammatory dermatoses of the breast in women of reproductive age. There are an increasing number of reports of IGM accompanied by extramammary manifestations, notably erythema nodosum.
MEK inhibition may be a new therapeutic pathway to treat disorders demonstrating focal acantholytic dyskeratosis, including Darier disease and Grover disease.
Retinoids are standard therapy for patients with severe ichthyoses and disorders of keratinization. The promise of a safe and effective topical isotretinoin would be a welcome therapeutic advance.
To improve the practice of dermatology, while being stimulating, practical, thought-provoking, and enlightening by offering critical perspectives on current dermatologic literature meant to be used in the clinic today and in the future.
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