DW Insights & Inquiries
Confluent and Reticulated Papillomatosis of Gougerot and Carteaud is usually seen in adolescents and young adults. The etiology of CARP remains to be determined, and further studies will judge its precise relationship to acanthosis nigricans.
Necrotizing infundibular (ostial) crystalline folliculitis is an underrecognized disorder characterized by folliculocentric waxy papules in the seborrheic areas of adult patients. An increasing number of cases are drug related.
PENs may present as solitary or multiple lesions. Multiple lesions presenting in childhood warrant consideration of Cowden syndrome and Multiple Endocrine Neoplasia Type 2B.
Case reports and retrospective studies have demonstrated dupilumab’s efficacy in treating bullous pemphigoid. Perhaps approval of dupilumab for bullous pemphigoid is on the horizon.
Advances in genetics and molecular biology have identified pathways confirming the usefulness of targeted therapies in those patients with systemic juvenile xanthogranulomas harboring specific mutations.
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