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DW Insights & Inquiries

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An infographic showing the role JAK plays in inflammation for DWII | American Academy of Dermatology (AAD).
JAK inhibitors battle in the heavyweight class

JAK inhibitors may cause weight gain. Although the precise pathomechanism is unknown, leptin dysregulation may be involved. Dermatologists must counsel patients treated with JAK inhibitors about the risk of weight gain.

A Merkel cell carcinoma growing below the eye of a man | American Academy of Dermatology (AAD).
Primary cutaneous SMARCA4-deficient cutaneous tumor

Dermatologists may rarely encounter SMARCA4-deficient undifferentiated malignant neoplasms, either as primary cutaneous tumors or as metastatic lesions.

Card image for DWII on allergen of the year 2025 showing the face of a man with a darker skin tone whose skin is showing signs of an allergic reaction | American Academy of Dermatology (AAD)
The 2025 Allergen of the Year is to dye for

Toluene-2,5-diamine sulfate (PTDS) may be an allergen but may also be used as a substitute in some patients allergic to the hair dye paraphenylene diamine.

Card image of a spider angioma on a lighter skin tone for a DWII about topical timolol treatment | American Academy of Dermatology (AAD)
Topical timolol for spider angiomas

Spider angiomas are common lesions that may be secondary to underlying conditions, notably pregnancy or chronic liver disease. Topical timolol may be a valuable option for those who prefer a nonsurgical approach to therapy.

Card image for DWII about erectile dysfunction in dermatology, showing dermatitis of the scalp | American Academy of Dermatology (AAD)
Erectile dysfunction in dermatology: A silent epidemic

Erectile dysfunction (ED) is associated with chronic inflammatory disorders, including psoriasis, seborrheic dermatitis, hidradenitis suppurativa, atopic dermatitis, and others.

Card image of digital mucous cysts for DWII | American Academy of Dermatology (AAD)
Injecting ideas (and therapies) in digital mucous cysts

Digital mucous (myxoid) cysts are often associated with osteoarthritis. Multiple therapeutic maneuvers may be utilized, but the best results remain with surgical excision.


The mission of DW Insights & Inquiries

To improve the practice of dermatology, while being stimulating, practical, thought-provoking, and enlightening by offering critical perspectives on current dermatologic literature meant to be used in the clinic today and in the future.

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