DW Insights & Inquiries
Diagnosing IgG4-related skin disease requires careful clinical-pathological correlation because of its varied presentations. B-cell depletion therapy with biologic agents is promising a future surpassing steroid therapy for this disease.
Based on clinical, histologic, and laboratory criteria, pityriasis rosea may reliably be differentiated from pityriasis rosea-like eruptions caused by drugs, herbs, infections, or vaccinations.
The aryl hydrocarbon receptor plays a key role in inflammation. Understanding its pathophysiology has led to new therapeutic agents such as tapinarof.
JAK inhibitors may cause weight gain. Although the precise pathomechanism is unknown, leptin dysregulation may be involved. Dermatologists must counsel patients treated with JAK inhibitors about the risk of weight gain.
Dermatologists may rarely encounter SMARCA4-deficient undifferentiated malignant neoplasms, either as primary cutaneous tumors or as metastatic lesions.
Toluene-2,5-diamine sulfate (PTDS) may be an allergen but may also be used as a substitute in some patients allergic to the hair dye paraphenylene diamine.
To improve the practice of dermatology, while being stimulating, practical, thought-provoking, and enlightening by offering critical perspectives on current dermatologic literature meant to be used in the clinic today and in the future.
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