DW Insights & Inquiries
The IL-36/IL-36R axis is crucial in the pathogenesis and treatment of generalized pustular psoriasis. Researchers have demonstrated the pathway may be instrumental in several other inflammatory dermatoses, as shown in pyoderma gangrenosum.
The diagnosis of CM-AVM syndrome should be recognized by vascular lesions surrounded by pallor. The risk of associated central nervous system AVMs mandates diagnostic confirmation and appropriate imaging assessment.
The OX40/OX40 ligand signaling pathway is involved in the pathogenesis of atopic dermatitis. Current trials using OX40/OX40 ligand inhibitors are underway, which are promising.
POHE is a diagnosis of exclusion after vitiligo and post-inflammatory or medication-induced hypopigmentation are ruled out. POHE is likely due to a combination of actinic damage and intrinsic aging in those with lighter complexions.
Early recognition and treatment of the Cronkhite-Canada syndrome may significantly improve the prognosis of this potentially lethal disease.
Dermatologists should consider the diagnosis of AESOP (Adenopathy and Extensive Skin patch Overlying a Plasmactyoma). A significant number of cases are associated with polyneuropathy and/or POEMS syndrome.
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